April in Cayo Santa Maria is the sunniest month of the year. In April, the weather in Cayo Santa Maria is typically warm. Average daily high temperature in April is about 25 degrees above zero. On average, Cayo Santa Maria has 17 sunny, 8 rainy, and 5 partly cloudy days in April. The rains are usually moderate. April as well as February and March is considered the most comfortable time to visit Cayo Santa Maria.