In April, the weather in Cuiabá is typically hot. Average daily high temperature in April is about 29 degrees above zero. On average, Cuiabá has 20 rainy, 6 sunny, 3 partly cloudy, and 1 cloudy day in April. The rains are usually heavy. April as well as January, February, March, and October is considered the most uncomfortable time to visit Cuiabá.