April in Cartagena is the cloudiest month of the year. In April, the weather in Cartagena is typically hot. Average daily high temperature in April is about 30 degrees above zero. On average, Cartagena has 20 rainy, 8 cloudy, 1 sunny, and 1 partly cloudy day in April. The rains are usually heavy. April as well as May, June, July, and August is considered the most uncomfortable time to visit Cartagena.