August in Cayo Guillermo is the hottest month of the year. In August, the weather in Cayo Guillermo is typically hot. Average daily high temperature in August is about 29 degrees above zero. On average, Cayo Guillermo has 18 rainy, 11 sunny, and 2 partly cloudy days in August. The rains are usually heavy. August as well as June, July, September, and October is considered the most uncomfortable time to visit Cayo Guillermo.