September in Cayo Guillermo is the rainiest month of the year. In September, the weather in Cayo Guillermo is typically hot. Average daily high temperature in September is about 28 degrees above zero. On average, Cayo Guillermo has 21 rainy, 5 sunny, 3 partly cloudy, and 1 cloudy day in September. The rains are usually heavy. September as well as June, July, August, and October is considered the most uncomfortable time to visit Cayo Guillermo.