April in São Tomé is the hottest month of the year. In April, the weather in São Tomé is typically hot. Average daily high temperature in April is about 28 degrees above zero. On average, São Tomé has 15 rainy, 13 cloudy, and 2 sunny days in April. The rains are usually moderate. April as well as January, February, March, and October is considered the most uncomfortable time to visit São Tomé.